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Sizing Up Zepbound for Weight Loss

Chances are, you’ve heard of Ozempic and Mounjaro. But did you know that the FDA recently approved a highly potent injectable called Zepbound for weight loss?

Continue reading to learn all about Zepbound weight loss injections, including how they compare to similar drugs on the market.

What Is Zepbound?

Zepbound is an FDA-approved weight loss injectable for adults who are obese (BMI of 30+) or overweight (BMI of 27+) with at least one weight-related medical condition.

How Does Zepbound Work?

Like Mounjaro, Zepbound is comprised of tirzepatide. It is an GLP-1 receptor agonist and a dual GIP/glucagon peptide agonist that stimulates insulin production and reduces glucagon production. This keeps blood sugar levels stable and helps to prevent hunger cravings.

Ultimately, Zepbound works by controlling appetite, reducing the amount of food intake, promoting a feeling of fullness, and increasing metabolism.

Zepbound Dosing

Zepbound for weight loss is administered via a 2.5 mg weekly injection for the first month of treatment.

Dosing is subsequently increased to a 5 mg weekly injection for the next month. The maximum dosage for Zepbound is 15 mg per week.

Who Is a Good Candidate for Zepbound?

Zepbound is approved for overweight or obese adults who have been diagnosed with at least one weight-related condition, such as high blood pressure or high cholesterol.

It’s also an excellent option for those who have a substantial amount of weight to lose. In fact, according to some experts, Zepbound has the potential to produce similar weight loss results to that of bariatric surgery.

How Does Zepbound Compare to Other Weight Loss Injectables?


Both Zepbound and Mounjaro are tirzepatide injectables that can be used for weight loss. They are also administered at the same dose and schedule. However, one of the key differences lies in their FDA-approvals.

Mounjaro is FDA-approved for type 2 diabetes and may help patients lose weight. Whereas,  Zepbound is FDA-approved specifically for weight loss.

As such, patients who have been using Mounjaro off-label may be inclined to switch to Zepbound for weight loss.


Wegovy is another FDA-approved injectable for weight loss. It is given once a week and contains semaglutide rather than tirzepatide.

Semaglutide is a GLP-1 receptor agonist, which means that it stimulates the release of insulin and lowers blood sugar levels. While originally developed to treat type 2 diabetes, it was discovered to have an impact on weight loss by making you feel full faster, reducing calorie intake, and increasing metabolism.


Ozempic is another injectable medication made of semaglutide. It is FDA-approved for the management of type 2 diabetes and often used off-label for weight loss. In fact, many slimmed-down stars, such as Sharon Osbourne, have credited Ozempic for helping them shed unwanted pounds.

Is Zepbound More Effective Than Its Competitors?

Clinical studies have shown Zepbound to be extremely effective for weight loss. More specifically, the results of two clinical studies revealed that participants taking 15 milligrams (mg) of Zepbound lost 18% and 12% of their body weight compared to placebo groups.

Based on these findings, researchers contend that Zepbound is more effective than Wegovy for weight loss. Experts also believe that Zepbound has demonstrated itself to be the most effective weight loss medication on the market.

Learn More About Zepbound

If you’re interested in weight loss injections and would like to learn more about Zepbound, please call our office today to schedule a consultation with one of our specialists.

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